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- Colorectal cancer incidence: a spatio-temporal analysis in Southern Portugal 1998-2006Publication . São João, Ricardo; Papoila, Ana Luisa; Amaral Turkman, Antónia; Ribeiro, Conceição; Geraldes, Carlos; Miranda, AnaInvestigate the influence of geographical environment in colorectal cancer (CRC) incidence in Southern Portugal. Due to the important role of socioeconomic status in the risk of CRC, this variable has also been taken into account.
- HLA Allele and Haplotype Frequencies of the Portuguese Bone Marrow Donors RegistryPublication . São João, Ricardo; Papoila, Ana Luisa; Ligeiro, Dário; Trindade, HélderGenes in human leucocyte antigens (HLA) System are important in the study of autoimmune diseases and responsible for the rejection of transplants of organs and tissues. HLA genes are part of the human major histocompatibility complex (MHC) which is characterized by the presence of several multigene families, extensive polymorphism at many loci and significant linkage disequilibrium between alleles at particular loci. We analysed HLA-A,-B,-DRB1 locus phenotypes through a sample of 1,021 subjects that were randomly selected among the volunteers recruited by the Portuguese Bone Marrow Donors Registry (Cedace) in order to evaluate allele, gene, haplotype and phenotype frequencies. Allelic frequencies in each of the studied locus were obtained by direct counting. Maximum-likelihood haplotype frequencies were estimated using an expectation-maximization (EM) algorithm [2]. Locus phenotype and gene relative frequencies were estimated according to Baur and Danilov [1]. Hardy–Weinberg equilibrium were tested. The data presented is a definition of HLA genetic repertoire of Cedace with relevance on the strategic management for the increase of a more diverse register with clinical utility.
- Environment and health in children day care centersPublication . Neuparth, Nuno; Papoila, A.L.; Pedro, Catarina; Caires, Iolanda; Martins, José Miguel; Guarino, Maria Pedro; Paixão, Paulo; São João, Ricardo; Marques, TeresaThis project addresses a set of common clinical problems in the context of children attending day care centres. It is common sense that children get sick more often as soon as they start attending a day care centre on a daily basis and this is particularly true for some groups at risk, as wheezing infants and wheezing pre-school children
- Sobrevivência relativa do cancro colo-rectal e do estômago no sul de PortugalPublication . São João, Ricardo; Papoila, Ana Luisa; Miranda, AnaA análise de sobrevivência é de importância ímpar na área das Ciências Biomédicas, em particular na oncologia onde constitui um instrumento de monitorização das atividades de controlo do cancro. Dado que a morte de um doente poderá ficar a dever-se a outras causas que não o cancro e que a causa específica de morte pode ser desconhecida, foi proposta uma medida objetiva da sobrevivência designada por sobrevivência relativa, no sentido de identificar qual a contribuição da neoplasia em si para a sobrevivência. Não dependendo da causa específica de morte, esta é uma medida útil na monitorização da sobrevivência, permitindo comparações entre grupos étnicos, regiões e registos de cancro de base populacional. Com base nos casos diagnosticados entre 1998 e 2006, registados pelo Registo Oncologico Regional Sul (ROR-Sul), o presente estudo tem como objetivo estimar a sobrevivência relativa considerando 11859 e 21575 doentes diagnosticados com cancro do estômago e colo-rectal, respetivamente. Foi considerado um período de follow-up de cinco anos. Procurar-se- ́a identificar a existência de diferenças significa- tivas na sobrevivência relativa quanto ao tipo de neoplasia, idade, género e região geográfica.
- Modelação e projeção da incidência de cancro colo-rectal e do estômago no Sul de PortugalPublication . São João, Ricardo; Papoila, A.L.; Sousa, Bruno de; Miranda, AnaO presente estudo tem como ojetivos: a modelação da incidência de cancro do cólon, reto e do estômago no período 1998-2006, com recurso aos modelos APC e a projeção da taxa de incidência no período 2007-2010 para as referidas neoplasias com base nos modelos APC e em modelos lineares, log-lineares e não lineares.
- Stomach cancer incidence in Southern Portugal 1998-2006:a spatio-temporal analysisPublication . Papoila, Ana Luisa; Ribeiro, Conceição; São João, Ricardo; Geraldes, Carlos; Amaral Turkman, Antónia; Miranda, AnaUnderstanding geographical differences in health, particularly in small areas, became a major concern of epidemiologists. Geographical association studies and, more recently, several spatial disease mapping studies have emerged due to the development of new spatial statistical tools. Among other diseases, these methods are being applied to analyze cancer data. However, in this kind of studies, it is of utmost importance to also investigate the influence of temporal variability and that is why spatio-temporal studies became so popular. The aim of this study is to investigate spatial and temporal trends for the incidence of this type of cancer. This retrospective population-based study is based on data on all stomach cancers registered by the Southern Portuguese Cancer Registry (ROR Sul) between 1998 and 2006. Because several studies have underlined the important role of socioeconomic status in cancer risk, information on this variable has also been taken into account. Bayesian hierarchical models were applied to model stomach incidence at a county level and resulting relative risks were used to build risk maps for cancer incidence. Age-Period-Cohort models were also applied.
- Stomach cancer incidence in Southern Portugal 1998-2006: A spatio-temporal analysisPublication . Papoila, Ana Luisa; Riebler, Andrea; Amaral-Turkman, Antónia; São João, Ricardo; Ribeiro, Conceição; Geraldes, Carlos; Miranda, AnaStomach cancer belongs to the most common malignant tumors in Portugal. Main causal factors are age, dietary habits, smoking, and Helicobacter pylori infections. As these factors do not only operate on different time dimensions, such as age, period, or birth cohort, but may also vary along space, it is of utmost interest to model temporal and spatial trends jointly. In this paper, we analyze incidence of stomach cancer in Southern Portugal between 1998 and 2006 for females and males jointly using a spatial multivariate age-period-cohort model. Thus, we avoid age aggregation and allow the exploration of heterogeneous time trends between males and females across age, period, birth cohort, and space. Model estimation is performed within a Bayesian setting assuming (gender specific) smoothing priors. Our results show that the posterior expected rate of stomach cancer is decreasing for all counties in Southern Portugal and that males around 70 have a two times higher risk of getting stomach cancer compared with their female counterparts. We further found that, except for some few counties, the spatial influence is almost constant over time and negligible in the southern counties of Southern Portugal.