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Advisor(s)
Abstract(s)
Accurate predictive tools are key factors for cancer care. Phase angle (PhA) has been proposed as a marker of
cellular health, particularly of cell-membrane integrity. Cutoff values have been proposed, including for cancer
survivors. This study aimed to assess the usefulness of the proposed PhA cutoff, as a marker of bioelectrical
impedance analysis (BIA) assessed health-status, and functional capacity in breast cancer (BC) survivors. This
cross-sectional study included 25 women (50.6 ± 8.6 yrs) survivors of BC, divided into two groups according to
the PhA reference value of 5.6◦ (group 1 [G1]: PhA ≤ 5.6◦ [n=13]; group 2 [G2]: PhA > 5.6◦ [n=12]) (Gupta
et al. 2008). BIA-assessed health status parameters included: extracellular water (ECW), intracellular water
(ICW), total body water (TBW), PhA, body mass, fat-free mass, muscle mass, body cell mass (BCM). Four
functional tests were performed: 30 s chair-stand test, timed up and go test, ball throw test and 6-minute walking
test. Results showed G2 had lower ECW/ICW ratio (p=0.001; ES=1.2), ECW/BCM ratio (p=0.001; ES=3.2) and
ECW/TBW ratio (p=0.001; ES=4.8). There was no difference in functional capacity between groups. The results
of the present study show that patients with higher PhA values have a higher ICW values and preservation in the
ECW/ICW ratio, suggesting it’s a better cell membrane quality and integrity. Relation of both PhA and cell
membrane integrity with functional capacity warrants further research.
Description
Keywords
cancer patients bioimpedance hydration functional tests
Citation
Martins, A. D.; Oliveira,R,; Brito, J.P.; Costa, T,; Ramalho, F.; Pimenta,N. & Santos-Rocha, R. (2021). Phase angle cutoff value as a marker of the health status and functional capacity in breast cancer survivors. Physiology & Behavior, 235, 1-5 pp.
Publisher
www.elsevier.com/locate/physbeh