Browsing by resource type "review"
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- Dairy products and inflammation: a review of the clinical evidencePublication . Bordoni, A.; Danesi, F.; Dardevet, D.; Fernandez, A.; Gille, D.; Santos, C.; Pinto, Paula; Re, R.; Rémond, D.; Shahar, D.; Vergères, G.Inflammation is a major biological process regulating the interaction between organisms and the environment, including the diet. Because of the increase in chronic inflammatory diseases, and in light of the immune-regulatory properties of breastfeeding, the ability of dairy products to modulate inflammatory processes in humans is an important but unresolved issue. Here, we report a systematic review of 52 clinical trials investigating inflammatory markers in relation to the consumption of dairy products. An inflammatory score (IS) was defined to quantitatively evaluate this interaction. The IS was significantly positive for the entire data set, indicating an anti-inflammatory activity in humans. When the subjects were stratified according to their health status, the IS was strongly indicative of an anti-inflammatory activity in subjects with metabolic disorders and of a pro-inflammatory activity in subjects allergic to bovine milk. Stratifying the data by product categories associated both low-fat and high-fat products, as well as fermented products, with an anti-inflammatory activity. Remarkably, the literature is characterized by a large gap in knowledge on bioavailability of bioactive nutrients. Future research should thus better combine food and nutritional sciences to adequately follow the fate of these nutrients along the gastrointestinal and metabolic axes.
- Effects of insect consumption on human health: a systematic review of human studiesPublication . Cunha, Nair; Andrade, Vanda; Ruivo, Paula; Pinto, PaulaInsects have been consumed as food in diverse cultures worldwide, gaining recognition as a sustainable and nutritious food source. This systematic review aims to update information on the impact of insect consumption on human health based on human randomized controlled trials (RCTs) and allergenicity assessment studies. Following PRISMA guidelines, studies published in the last 10 years were analyzed. From one-thousand and sixty-three retrieved references, nine RCTs and five allergenicity studies were analyzed. Post-prandial amino acid levels increased after insect protein consumption. In comparison with other protein sources, insect protein showed no significant differences in the area under the curve (AUC) values for essential amino acids but tended to have lower peaks and peak later. In terms of muscle protein synthesis, there were no significant differences between insect protein and other protein sources. Glucose levels did not differ; however, insulin levels were lower after the consumption of insect-based products. The effects on inflammatory markers and microbiota composition were inconclusive and the studies did not show significant effects on appetite regulation. Allergenicity assessments revealed a sensitisation and cross-reactivity between insect allergens and known allergens. A partial reduction of cross-allergenicity was observed via thermal processing. Insect protein is an adequate protein source with promising health benefits; however, further research is needed to fully understand its potential and optimise its inclusion into the human diet.
- Lactic acid bacteria: a sustainable solution against phytopathogenic agentsPublication . Saragoça, A.; Canha, H.; Varanda, Carla; Materatski, Patrick; Cordeiro, A.I.; Gama, J.Biological control agents (BCAs) are beneficial living organisms used in plant protection to control pathogens sustainably. Lactic acid bacteria (LAB) have gained attention in biopesticides due to their safety as recognized by the Food and Drug Administration. These bacteria possess antifungal properties, demonstrating inhibitory effects through nutrient competition or the production of antimicrobial metabolites. Numerous Lactobacillus species have shown the ability to inhibit pathogenic microorganisms, primarily through acid production. The organic acids secreted by LAB reduce the pH of the medium, creating a hostile environment for microorganisms. These organic acids are a primary inhibition mechanism of LAB. This article reviews several studies on LAB as BCAs, focusing on their inhibition modes. Additionally, it discusses the limitations and future challenges of using LAB to control phytopathogens for sustainable agriculture.
- Meta-analysis of the effects of foods and derived products containing ellagitannins and anthocyanins on cardiometabolic biomarkers: analysis of factors influencing variability of the individual responsesPublication . Garcia-Conessa, M.; Chambers, K.; Combet, E.; Pinto, Paula; Garcia-Aloy, M.; Andrés-Lacueva, C.; Pascual-Teresa, S.; Mena, P.; Ristic, A.; Hollands, W.; Kroon, P.; Rodríguez-Mateos, A.; Istas, G.; Kontogiorgis, C.; Rai, D.; Gibney, E.; Morand, C.; Espin, J.; González-Sarrías, A.Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin-and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose weremost significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation.
- Nanofertilizer use for adaptation and mitigation of the agriculture/climate change dichotomy effectsPublication . Saraiva, Raquel; Ferreira, Q.; Rodrigues, G.C.; Oliveira, MargaridaAgriculture is considered a significant climate change (CC) driver due to greenhouse gas (GHG) emissions and the loss of fertilizers that contribute to water eutrophication. On the other hand, climate change effects are already impacting agriculture, endangering food security. This paper explores the dichotomies of the effects of agriculture on CC as well as of CC on agriculture, focusing on the contribution that nanofertilizers can bring to this complex system in both directions. The strategies to reduce CC while adapting and mitigating its effects must be a global effort. It is not possible to focus only on the reduction in GHG emissions to stop the effects that are already being felt worldwide. Nanofertilizers, especially slow- and controlled-release nanofertilizers, can reduce the nutrient input and also boost productivity while mitigating some CC effects, such as soil nutrient imbalance and agricultural emissions. As so, this review highlights the benefits of nanofertilizers and their role as a part of the strategy to reduce the reach of CC and mitigate its ever-growing effects, and presents some guidelines for the increased use of these materials in order to enhance their efficacy in this strategy.
- Phosphorous nanofertilizers for Precise application in rice cultivation as an adaptation to climate changePublication . Saraiva, Raquel; Ferreira, Quirina; Rodrigues, Gonçalo C.; Oliveira, MargaridaRice is the staple food of more than half of the world’s population, which is still growing. The great dependence that agriculture, and rice specially, has on fertilizers alongside extreme events that result from climatic change creates an urge for adaptation. Fertilizers are expensive, finite and a potential environmental problem. Their precise application, by the use of slow-release nanofertilizers, thus avoiding losses and consequently reducing the pressure on water resources, is one step forward in this adaptation. It can reduce costs and protect the environment while ensuring food production. Phosphorous is very important for rice, since it is involved in its flowering and root development, and its low availability to the plants constitutes a serious problem. The delivery of phosphorous through the crop cycle in the form of slow-release phosphorus nanofertilizer (Pnf) instead of the conventional annual bulk application reduces the amount of nutrients applied and increases the absorption by the crop. Combining the fertilizing effect with the use of natural stimulant compounds such as chitosan can protect the crop from diseases and increase its resilience to stress. The use of Pnf reduces the pressure on water resources and avoids imbalances in soil nutrients, thus responding to climatic change challenges and abiotic stresses.