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Meta-analysis of the effects of foods and derived products containing ellagitannins and anthocyanins on cardiometabolic biomarkers: analysis of factors influencing variability of the individual responses

2018Review Open access
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authorProfile.affiliationInstituto Politécnico de Santarém, Escola Superior Agrária de Santarémpt_PT
dc.contributor.authorGarcia-Conessa, M.
dc.contributor.authorChambers, K.
dc.contributor.authorCombet, E.
dc.contributor.authorPinto, Paula
dc.contributor.authorGarcia-Aloy, M.
dc.contributor.authorAndrés-Lacueva, C.
dc.contributor.authorPascual-Teresa, S.
dc.contributor.authorMena, P.
dc.contributor.authorRistic, A.
dc.contributor.authorHollands, W.
dc.contributor.authorKroon, P.
dc.contributor.authorRodríguez-Mateos, A.
dc.contributor.authorIstas, G.
dc.contributor.authorKontogiorgis, C.
dc.contributor.authorRai, D.
dc.contributor.authorGibney, E.
dc.contributor.authorMorand, C.
dc.contributor.authorEspin, J.
dc.contributor.authorGonzález-Sarrías, A.
dc.date.accessioned2018-11-22T17:55:31Z
dc.date.available2018-11-22T17:55:31Z
dc.date.issued2018
dc.description.abstractUnderstanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin-and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose weremost significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation.pt_PT
dc.description.sponsorshipCOST (European Cooperation in Science and Technology); COST Action "POSITIVe"pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGarcia-Conesa, M. T. Chambers, K. Combet, E. ; Pinto, P et al. (2018). Meta-analysis of the effects of foods and derived products containing ellagitannins and anthocyanins on cardiometabolic biomarkers: analysis of factors influencing variability of the individual responses. Int. J. Mol. Sci. 19, 694pt_PT
dc.identifier.doi10.3390/ijms19030694pt_PT
dc.identifier.issn1422-0067
dc.identifier.otherID PubMed: 29495642
dc.identifier.otherWOS:000428309800051
dc.identifier.urihttp://hdl.handle.net/10400.15/2346
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationFA1403-POSITIVept_PT
dc.relationFA1403pt_PT
dc.relation.ispartofseries19;694
dc.relation.publisherversion10.3390/ijms19030694pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectellagitanninspt_PT
dc.subjectanthocyaninspt_PT
dc.subjectinterindividual variabilitpt_PT
dc.subjectcardiometabolic disorderspt_PT
dc.subjectmeta-analysispt_PT
dc.subjectpomegranatept_PT
dc.subjectnutspt_PT
dc.subjectberriespt_PT
dc.subjectred winept_PT
dc.subjectred grapespt_PT
dc.titleMeta-analysis of the effects of foods and derived products containing ellagitannins and anthocyanins on cardiometabolic biomarkers: analysis of factors influencing variability of the individual responsespt_PT
dc.typereview
dspace.entity.typePublication
oaire.citation.conferencePlaceBasel (SWITZERLAND)pt_PT
oaire.citation.issue3pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume19pt_PT
person.familyNamePaula S F S Pinto
person.givenNameMaria
person.identifier.ciencia-id011F-62A8-AE04
rcaap.rightsopenAccesspt_PT
rcaap.typereviewpt_PT
relation.isAuthorOfPublication2260faef-53cb-403f-a0ea-637298da3dc7
relation.isAuthorOfPublication.latestForDiscovery2260faef-53cb-403f-a0ea-637298da3dc7

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