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Bioaccessible raspberry extracts enriched in ellagitannins and ellagic acid derivatives have anti-neuroinflammatory properties

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dc.contributor.authorGarcia, Gonçalo
dc.contributor.authorPais, Teresa Faria
dc.contributor.authorPinto, Paula
dc.contributor.authorDobson, Gary
dc.contributor.authorMcDougall, Gordon J.
dc.contributor.authorStewart, Derek
dc.contributor.authorNunes Dos Santos, Cláudia
dc.date.accessioned2020-12-28T11:48:00Z
dc.date.available2020-12-28T11:48:00Z
dc.date.issued2020
dc.description.abstractChronic neuroinflammation associated with neurodegenerative disorders has been reported to be prevented by dietary components. Particularly, dietary (poly)phenols have been identified as having anti-inflammatory and neuroprotective actions, and their ingestion is considered a major preventive factor for such disorders. To assess the relation between (poly)phenol classes and their bioactivity, we used five different raspberry genotypes, which were markedly different in their (poly)phenol profiles within a similar matrix. In addition, gastro-intestinal bio-accessible fractions were produced, which simulate the (poly)phenol metabolites that may be absorbed after digestion, and evaluated for anti-inflammatory potential using LPS-stimulated microglia. Interestingly, the fraction from genotype 2J19 enriched in ellagitannins, their degradation products and ellagic acid, attenuated pro-inflammatory markers and mediators CD40, NO, TNF-α, and intracellular superoxide via NF-κB, MAPK and NFAT pathways. Importantly, it also increased the release of the anti-inflammatory cytokine IL-10. These effects contrasted with fractions richer in anthocyanins, suggesting that ellagitannins and its derivatives are major anti-inflammatory (poly)phenols and promising compounds to alleviate neuroinflammation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGarcia, G.; Pais, T.F.; Pinto, P.; Dobson, G.; McDougall, G.J.; Stewart, D. & Santos, C.N. (2020) Bioaccessible raspberry extracts enriched in ellagitannins and ellagic acid derivatives have anti-neuroinflammatory properties. Antioxidants, 12 (9), 970.pt_PT
dc.identifier.doi10.3390/antiox9100970pt_PT
dc.identifier.issn2076-3921
dc.identifier.urihttp://hdl.handle.net/10400.15/3165
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationiNOVA4Health—UID/Multi/04462/2013, a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreementpt_PT
dc.relationRural & Environment Science & Analytical Services Division of the Scottish Government (G.D., G.J.M. and D.S.), OptiBerry FACCE SURPLUS ERA-NET (D.S.), EUBERRY FP7-KBBE-2010-4265942 (G.G., T.P., G.D., G.J.M., D.S. and C.N.S.)pt_PT
dc.relationEuropean Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 804229 (CNS)pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-3921/9/10/970pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPolyphenols metabolitespt_PT
dc.subjectResearch Subject Categories::NATURAL SCIENCESpt_PT
dc.subjectneuroinflamationpt_PT
dc.subjectgastro-intestinal digestionpt_PT
dc.subjectneuroinflammationpt_PT
dc.subjectmicrogliapt_PT
dc.titleBioaccessible raspberry extracts enriched in ellagitannins and ellagic acid derivatives have anti-neuroinflammatory propertiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue10pt_PT
oaire.citation.startPage970pt_PT
oaire.citation.titleAntioxidantspt_PT
oaire.citation.volume9pt_PT
person.familyNamePaula S F S Pinto
person.familyNameNunes dos Santos
person.givenNameMaria
person.givenNameMaria Cláudia
person.identifierV-2405-2019
person.identifier.ciencia-id011F-62A8-AE04
person.identifier.ciencia-id1B12-173A-E79B
person.identifier.orcid0000-0002-5809-1924
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2260faef-53cb-403f-a0ea-637298da3dc7
relation.isAuthorOfPublicationec316dbb-62ad-4178-bc1b-bf7beb7eef1d
relation.isAuthorOfPublication.latestForDiscoveryec316dbb-62ad-4178-bc1b-bf7beb7eef1d

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