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Combined effect of interventions with pure or enriched mixtures of (poly)phenols and anti-diabetic medication in type 2 diabetes management: a meta-analysis of randomized controlled human trials: review

2020Journal article Open access
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dc.contributor.authorRaimundo, Ana F.
dc.contributor.authorFélix, F.
dc.contributor.authorAndrade, R.
dc.contributor.authorGarcía‑Conesa, M.T.
dc.contributor.authorGonzález‑Sarrías, A.
dc.contributor.authorGilsa‑Lopes, J.
dc.contributor.authorÓ, D. do
dc.contributor.authorRaimundo, A.
dc.contributor.authorRibeiro, R.
dc.contributor.authorRodiguez-Mateos, A.
dc.contributor.authorSantos, C.N.
dc.contributor.authorSchär, M.
dc.contributor.authorSilva, A.
dc.contributor.authorCruz, I.
dc.contributor.authorWang, B.
dc.contributor.authorPinto, Paula
dc.contributor.authorMenezes, R.
dc.date.accessioned2021-05-24T11:44:22Z
dc.date.available2021-05-24T11:44:22Z
dc.date.issued2020
dc.description.abstractPurpose: (Poly)phenols have been reported to confer protective effects against type 2 diabetes but the precise association remains elusive. This meta-analysis aimed to assess the effects of (poly)phenol intake on well-established biomarkers in people with type 2 diabetes or at risk of developing diabetes. Methods: A systematic search was conducted using the following selection criteria: (1) human randomized controlled trials involving individuals with prediabetes and type 2 diabetes; (2) one or more of the following biomarkers: glucose, glycated haemoglobin (HbA1c), insulin, pro-insulin, homeostatic model assessment of insulin resistance (HOMA-IR), islet amyloid polypeptide (IAPP)/amylin, pro-IAPP/pro-amylin, glucagon, C-peptide; (3) chronic intervention with pure or enriched mixtures of (poly)phenols. From 488 references, 88 were assessed for eligibility; data were extracted from 27 studies and 20 were used for meta-analysis. The groups included in the meta-analysis were: (poly)phenol mixtures, isoflavones, flavanols, anthocyanins and resveratrol. Results: Estimated intervention/control mean differences evidenced that, overall, the consumption of (poly)phenols contributed to reduced fasting glucose levels (- 3.32 mg/dL; 95% CI - 5.86, - 0.77; P = 0.011). Hb1Ac was only slightly reduced (- 0.24%; 95% CI - 0.43, - 0.044; P = 0.016) whereas the levels of insulin and HOMA-IR were not altered. Subgroup comparative analyses indicated a stronger effect on blood glucose in individuals with diabetes (- 5.86 mg/dL, 95% CI - 11.34, - 0.39; P = 0.036) and this effect was even stronger in individuals taking anti-diabetic medication (- 10.17 mg/dL, 95% CI - 16.59, - 3.75; P = 0.002). Conclusions: Our results support that the consumption of (poly)phenols may contribute to lower glucose levels in individuals with type 2 diabetes or at risk of diabetes and that these compounds may also act in combination with anti-diabetic drugs.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRaimundo AF, Félix F, Andrade R, García-Conesa MT, González-Sarrías A, Gilsa-Lopes J, do Ó D, Raimundo A, Ribeiro R, Rodriguez-Mateos A, Santos CN, Schär M, Silva A, Cruz I, Wang B, Pinto P, Menezes R. Combined effect of interventions with pure or enriched mixtures of (poly)phenols and anti-diabetic medication in type 2 diabetes management: a meta-analysis of randomized controlled human trials. Eur J Nutr. 2020 Jun;59(4):1329-1343. doi: 10.1007/s00394-020-02189-1. PMID: 32052147.pt_PT
dc.identifier.doihttps://doi.org/10.1007/s00394-020-02189-1pt_PT
dc.identifier.eissn1436-6215
dc.identifier.issn1436-6207
dc.identifier.urihttp://hdl.handle.net/10400.15/3489
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationCOST Action FA1403—POSITIVe. iNOVA4Health—UID/Multi/04462/2019, a program financially supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement is acknowledged.pt_PT
dc.relationFunding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC), is gratefully acknowledged. UIDP/04748/2020, a program financially supportpt_PT
dc.relationThis study was also supported by FCT via PTDC/BIA-MOL31104/2017 and UID/Multi/04462/2019-SubProj iNOVA4Health 44 to RM, SFRH/PD/BD/135504/2018 to AFR, SFRH/BPD/110426/2015 to RR. Sociedade Portuguesa de Diabetologia for the Nuno Castelo-Branco Prize—2016 attributed to RM and RR.pt_PT
dc.relation.publisherversionhttps://pubmed.ncbi.nlm.nih.gov/32052147/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntidiabetic therapypt_PT
dc.subjectDiabetespt_PT
dc.subjectGlucosept_PT
dc.subjectHb1Acpt_PT
dc.subjectInsulinpt_PT
dc.subjectPolyphenolpt_PT
dc.titleCombined effect of interventions with pure or enriched mixtures of (poly)phenols and anti-diabetic medication in type 2 diabetes management: a meta-analysis of randomized controlled human trials: reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1343pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage1329pt_PT
oaire.citation.titleEuropean Journal of Nutritionpt_PT
oaire.citation.volume59pt_PT
person.familyNamePaula S F S Pinto
person.givenNameMaria
person.identifier.ciencia-id011F-62A8-AE04
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2260faef-53cb-403f-a0ea-637298da3dc7
relation.isAuthorOfPublication.latestForDiscovery2260faef-53cb-403f-a0ea-637298da3dc7

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