Dairy products and inflammation: a review of the clinical evidence

Bordoni, A.; Danesi, F.; Dardevet, D.; Fernandez, A.; Gille, D.; Santos, C.; Pinto, Paula; Re, R.; Rémond, D.; Shahar, D.; Vergères, G.

Publication

Dairy products and inflammation: a review of the clinical evidence

2017Review

authorProfile.affiliation	Instituto Politécnico de Santarém, Escola Superior Agrária de Santarém	pt_PT
dc.contributor.author	Bordoni, A.
dc.contributor.author	Danesi, F.
dc.contributor.author	Dardevet, D.
dc.contributor.author	Fernandez, A.
dc.contributor.author	Gille, D.
dc.contributor.author	Santos, C.
dc.contributor.author	Pinto, Paula
dc.contributor.author	Re, R.
dc.contributor.author	Rémond, D.
dc.contributor.author	Shahar, D.
dc.contributor.author	Vergères, G.
dc.date.accessioned	2018-11-22T15:29:00Z
dc.date.available	2018-11-22T15:29:00Z
dc.date.issued	2017
dc.description.abstract	Inflammation is a major biological process regulating the interaction between organisms and the environment, including the diet. Because of the increase in chronic inflammatory diseases, and in light of the immune-regulatory properties of breastfeeding, the ability of dairy products to modulate inflammatory processes in humans is an important but unresolved issue. Here, we report a systematic review of 52 clinical trials investigating inflammatory markers in relation to the consumption of dairy products. An inflammatory score (IS) was defined to quantitatively evaluate this interaction. The IS was significantly positive for the entire data set, indicating an anti-inflammatory activity in humans. When the subjects were stratified according to their health status, the IS was strongly indicative of an anti-inflammatory activity in subjects with metabolic disorders and of a pro-inflammatory activity in subjects allergic to bovine milk. Stratifying the data by product categories associated both low-fat and high-fat products, as well as fermented products, with an anti-inflammatory activity. Remarkably, the literature is characterized by a large gap in knowledge on bioavailability of bioactive nutrients. Future research should thus better combine food and nutritional sciences to adequately follow the fate of these nutrients along the gastrointestinal and metabolic axes.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Bordoni,A.; Danesi, F.; Dardevet, D.; Dupont,D.; Fernandez, A.; Gille, D.; Santos, C.N. ;Pinto, P.; Re, R. ; Rémond,D.; Shahar, D. & Vergères, G. (2017) Dairy products and inflammation: A review of the clinical evidence, Critical Reviews in Food Science and Nutrition, 57:12, 2497-2525, DOI: 10.1080/10408398.2014.967385	pt_PT
dc.identifier.doi	10.1080/10408398.2014.967385	pt_PT
dc.identifier.issn	1040-8398
dc.identifier.uri	http://hdl.handle.net/10400.15/2345
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Taylor & Francis Open	pt_PT
dc.relation	Pest-OE/EQB/LA0004/2011 IF/01097/2013	pt_PT
dc.relation.publisherversion	https://doi.org/10.1080/10408398.2014.967385	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	pt_PT
dc.subject	Produto lácteo	pt_PT
dc.subject	Sistema imunitário	pt_PT
dc.subject	Doença crónica	pt_PT
dc.subject	Obesidade	pt_PT
dc.subject	Milk	pt_PT
dc.subject	Cheese	pt_PT
dc.subject	Chronic diseases	pt_PT
dc.subject	Obesity	pt_PT
dc.subject	Health	pt_PT
dc.title	Dairy products and inflammation: a review of the clinical evidence	pt_PT
dc.type	review
dspace.entity.type	Publication
oaire.citation.conferencePlace	Philadelphia (USA)	pt_PT
oaire.citation.endPage	2525	pt_PT
oaire.citation.issue	57	pt_PT
oaire.citation.startPage	2497	pt_PT
oaire.citation.title	Critical Reviews in Food Science and Nutrition	pt_PT
oaire.citation.volume	12	pt_PT
person.familyName	Paula S F S Pinto
person.givenName	Maria
person.identifier.ciencia-id	011F-62A8-AE04
rcaap.rights	openAccess	pt_PT
rcaap.type	review	pt_PT
relation.isAuthorOfPublication	2260faef-53cb-403f-a0ea-637298da3dc7
relation.isAuthorOfPublication.latestForDiscovery	2260faef-53cb-403f-a0ea-637298da3dc7