Percorrer por autor "Ribeiro, Oscar"
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- Differential Response to Cognitive Stimulation in Moderate Versus Moderately Severe Alzheimer’s DiseasePublication . Justo-Henriques, Susana; Silva, Rosa C. Gomes; Carvalho, Janessa O.; Pérez-Sáez, Enrique; São João, Ricardo; Ribeiro, OscarAlzheimer’s disease (AD) is characterized by impairments across several neurocognitive domains, particularly memory and executive function. The study explored the effectiveness of an individual cognitive stimulation (iCS) program on cognitive outcomes in older adults with moderate to moderately severe AD. A multicentre randomized controlled trial was conducted with 80 Portuguese older adults (Mage : 83.0 ± 7.1 years) with AD. Participants were randomly assigned to either iCS (n = 39; 49%) or treatment as usual (n = 41; 51%). Alzheimer’s Disease Severity (ADS) categorized two groups based on Mini-Mental State Examination score: 10–14 in the ADS moderately severe group and 15–20 in the ADS moderate group. In participants with moderate AD, iCS led to significant improvements in memory- related outcomes (particularly Memory Assessment Test) and a trend toward improvement in global cognition. In contrast, no significant effects were observed in participants with moderately severe AD. Meta-analytic comparisons and meta-regression confirmed a significant difference in intervention effectiveness between severity levels. iCS was significantly more effective in individuals with moderate AD than in those with moderately severe AD. This difference in responsiveness between severity levels was statistically confirmed (Q = 11.29, p < .001). iCS was effective in enhancing memory in individuals with moderate AD, with additional indications of global cognitive benefit. However, no meaningful effects were observed in participants with moderately severe impairment, suggesting diminished responsiveness to iCS as disease severity increases.
- Digital and Analogical Cognitive Stimulation in Older Adults with Alzheimer’s Disease: A Multicenter Randomized Controlled Trial Study ProtocolPublication . Henriques, Susana I. Justo; Padeiro, Miguel; Silva, Rosa C. G.; Macedo, Joana; Machado, Flávia Borges; São João, Ricardo M. V. de; Ribeiro, OscarThe growing incidence of neurodegenerative diseases in older adults, with the prevalence of Alzheimer’s disease, progressively affects their quality of life. Cognitive stimulation is a psychosocial intervention that has shown consistent benefits in the lives of people with dementia from mild to moderate stages. The present study aims to evaluate the effectiveness of digital and analogical cognitive stimulation, when compared with usual care, on overall cognitive function, emotional state, and quality of life. It also aims to investigate whether institutional and territorial characteristics of social care services moderate these effects. This is a three-arm multicenter randomized controlled trial with repeated measures (pre-intervention, post-intervention, and follow-up). The intervention consists of 24 individually applied (digital and analogical) cognitive stimulation sessions, twice a week, for 12 weeks, in two intervention groups. The control group receives usual care. The study follows the recommendations of the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT 2025), including the extension for non-pharmacological interventions. The sample size is estimated at 222 older adults with a probable diagnosis of mild to moderate Alzheimer’s disease. Sociodemographic, social, health and clinical data, as well as information on care provider institutions, will be collected and analyzed. Outcomes include cognition (global cognition, memory, and executive function), emotional state (anxiety and depression), and quality of life. All outcomes will be assessed at baseline, endpoint, and follow-up, with comparisons between the interven tion groups and the control group.