Publication
Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties
| authorProfile.affiliation | Instituto Politécnico de Santarém, Escola Superior Agrária de Santarém | pt_PT |
| dc.contributor.author | Justino, Jorge | |
| dc.contributor.author | Rauter, Amélia | |
| dc.contributor.author | Dias, Catarina | |
| dc.contributor.author | Martins, Alice | |
| dc.contributor.author | Branco, Isabel | |
| dc.contributor.author | Goulart, Margarida | |
| dc.contributor.author | Nogueira, José | |
| dc.contributor.author | Neng, Nuno | |
| dc.contributor.author | Silva, Filipa | |
| dc.contributor.author | Trevitt, Clare | |
| dc.contributor.author | Waltho, Jon | |
| dc.date.accessioned | 2013-12-09T16:10:42Z | |
| dc.date.available | 2013-12-09T16:10:42Z | |
| dc.date.issued | 2012-06 | |
| dc.description | Estudo de produção agronómica de espécis da salvia com vista à avaliação dos seus constituintes para o potencial controlo da doença de Alzaimer | por |
| dc.description.abstract | Salvia sclareoides is an aromatic herb native to Portugal, of which phenolic content (Folin–Ciocalteau method), chemical profile (HPLC/DAD), antioxidant activity (DPPH, β-carotene/linoleic acid assays), acute toxicity (MTT method, adapted for non-adherent cells), genotoxicity (short-term chromosomal aberration assay) and prion binding properties were evaluated in the acetone, water, ethanol, methanol and n-butanol extracts. The latter presented the highest phenolic content and antioxidant activity (DPPH assay), and was the single one with the flavonoids (+)-catechin, kaempferol O-glucoside and quercetin. Vanillic acid was the major component of all extracts but gallic, gentisic, caffeic, syringic, coumaric and ferulic acids were also found in some extracts. Only the n-butanol extract had components binding to the cellular form of human prion protein detected by NMR which showed specificity for two regions of the folded domain and for the unstructured N-terminal region. Extracts were not cytotoxic nor genotoxic, reinforcing the potential of S. sclareoides for nutraceutical purposes. | por |
| dc.description.sponsorship | Este trabalho é financiado por Fundos FEDER através do Programa Operacional Fatores de Competitividade – COMPETE e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projeto «Refª do Projecto» | por |
| dc.identifier.citation | Justino,J.;Rauter,A.;Dias,C.;Martins.A.;Branco,I.;Goulart,M. (2012).Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties.Food Chemistry,132,1930-1935. Disponível em : http://www.sciencedirect.com/science/article/pii/S0308814611017833 | por |
| dc.identifier.issn | 0308-8146 | |
| dc.identifier.uri | http://hdl.handle.net/10400.15/882 | |
| dc.language.iso | por | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Elsevier | por |
| dc.relation | Ref do Projeto - PTDC/AGR-AAM/66414/2006 | por |
| dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0308814611017833 | por |
| dc.subject | Salvia sclareoides | por |
| dc.subject | Phenolic profile | por |
| dc.subject | Antioxidant activity | por |
| dc.subject | Cytotoxicity | por |
| dc.subject | Genotoxicity | por |
| dc.subject | Prion binding | por |
| dc.title | Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 1935p. | por |
| oaire.citation.startPage | 1930p. | por |
| oaire.citation.title | Food Chemistry | por |
| oaire.citation.volume | 132 | por |
| person.familyName | Justino | |
| person.familyName | Vinagre Marques da Silva | |
| person.givenName | Jorge | |
| person.givenName | Filipa | |
| person.identifier | https://scholar.google.pt/citations?hl=pt-PT&user=TcUz9ZAAAAAJ | |
| person.identifier.ciencia-id | B610-66DA-A3AC | |
| person.identifier.orcid | 0000-0003-3114-5926 | |
| person.identifier.orcid | 0000-0003-4700-2938 | |
| person.identifier.scopus-author-id | 22942414000 | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |
| relation.isAuthorOfPublication | 3e483773-36b8-4a7b-82f3-c0a39f6a7fa9 | |
| relation.isAuthorOfPublication | 344bf736-31c9-4a35-844c-67a176174a44 | |
| relation.isAuthorOfPublication.latestForDiscovery | 3e483773-36b8-4a7b-82f3-c0a39f6a7fa9 |