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The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats

2020-05-30Journal article Open access
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dc.contributor.authorMurillo-RodrĆ­guez, Eric
dc.contributor.authorMillƔn-Aldaco, Diana
dc.contributor.authorArankowsky-Sandoval, Gloria
dc.contributor.authorYamamoto, Tetsuya
dc.contributor.authorCid, Luis
dc.contributor.authorMonteiro, Diogo
dc.contributor.authorRocha, Nuno Barbosa
dc.contributor.authorTelles-Correia, Diogo
dc.contributor.authorTeixeira, Diogo S.
dc.contributor.authorVeras, AndrƩ Barciela
dc.contributor.authorBudde, Henning
dc.contributor.authorMachado, SĆ©rgio
dc.contributor.authorImperatori, Claudio
dc.contributor.authorTorterolo, Pablo
dc.date.accessioned2020-06-02T16:35:26Z
dc.date.available2021-05-30T00:30:11Z
dc.date.issued2020-05-30
dc.description.abstractRationale The nuclear receptor retinoid X receptor (RXR) belongs to a nuclear receptor superfamily that modulates diverse functions via homodimerization with itself or several other nuclear receptors, including PPARĪ±. While the activation of PPARĪ± by natural or synthetic agonists regulates the sleep-wake cycle, the role of RXR in the sleep modulation is unknown. Objectives We investigated the effects of bexarotene (Bexa, a RXR agonist) or UVI 3003 (UVI, a RXR antagonist) on sleep, sleep homeostasis, levels of neurochemical related to sleep modulation, and c-Fos and NeuN expression. Methods The sleep-wake cycle and sleep homeostasis were analyzed after application of Bexa or UVI. Moreover, we also evaluated whether Bexa or UVI could induce effects on dopamine, serotonin, norepinephrine epinephrine, adenosine, and acetylcholine contents, collected from either the nucleus accumbens or basal forebrain. In addition, c-Fos and NeuN expression in the hypothalamus was determined after Bexa or UVI treatments. Results Systemic application of Bexa (1 mM, i.p.) attenuated slow-wave sleep and rapid eye movement sleep. In addition, Bexa increased the levels of dopamine, serotonin, norepinephrine epinephrine, adenosine, and acetylcholine sampled from either the nucleus accumbens or basal forebrain. Moreover, Bexa blocked the sleep rebound period after total sleep deprivation, increased in the hypothalamus the expression of c-Fos, and decreased NeuN activity. Remarkably, UVI 3003 (1 mM, i.p.) induced opposite effects in sleep, sleep homeostasis, neurochemicals levels, and c-Fos and NeuN activity. Conclusions The administration of RXR agonist or antagonist significantly impaired the sleep-wake cycle and exerted effects on the levels of neurochemicals related to sleep modulation. Moreover, Bexa or UVI administration significantly affected c-Fos and NeuN expression in the hypothalamus. Our findings highlight the neurobiological role of RXR on sleep modulation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMurillo-Rodrƭguez, E., MillƔn-Aldaco, D., Arankowsky-Sandoval, G. et al. The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats. Psychopharmacology (2020). https://doi.org/10.1007/s00213-020-05518-8pt_PT
dc.identifier.doi10.1007/s00213-020-05518-8pt_PT
dc.identifier.issn0033-3158
dc.identifier.urihttp://hdl.handle.net/10400.15/2911
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Nature [academic journals on nature.com]pt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00213-020-05518-8pt_PT
dc.subjectAdenosinept_PT
dc.subjectDopaminept_PT
dc.subjectRetinoid X receptorpt_PT
dc.subjectSerotoninpt_PT
dc.subjectSleeppt_PT
dc.titleThe retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in ratspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage19pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePsychopharmacologypt_PT
oaire.citation.volume237pt_PT
person.familyNameCid
person.familyNameMonteiro
person.givenNameLuis
person.givenNameDiogo
person.identifier559047
person.identifierF-1202-2015
person.identifier.ciencia-idCE17-DDDC-86B2
person.identifier.ciencia-idED1F-6228-E26F
person.identifier.orcid0000-0001-8156-3291
person.identifier.orcid0000-0002-7179-6814
person.identifier.ridK-3281-2012
person.identifier.scopus-author-id55507520600
person.identifier.scopus-author-id56437945500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf89cbc0e-02e0-4077-91a5-b35d685c68c3
relation.isAuthorOfPublication6b2e136e-b810-49d4-964d-36c9537dcf83
relation.isAuthorOfPublication.latestForDiscovery6b2e136e-b810-49d4-964d-36c9537dcf83

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