Publication
Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats
| authorProfile.affiliation | Instituto Politécnico de Santarém, Escola Superior Agrária de Santarém | pt_PT |
| dc.contributor.author | Rauter, A. P. | |
| dc.contributor.author | Martins, A. | |
| dc.contributor.author | Borges, C. | |
| dc.contributor.author | Mota-Filipe, H. | |
| dc.contributor.author | Pinto, R. | |
| dc.contributor.author | Justino, Jorge | |
| dc.date.accessioned | 2011-08-09T09:43:16Z | |
| dc.date.available | 2011-08-09T09:43:16Z | |
| dc.date.issued | 2010-03-22 | |
| dc.description.abstract | The antihyperglycaemic effect of eight standard flavonoids, previously identified in the ethanol extract of the claimed antidiabetic plant Genista tenera, was evaluated on streptozotocin (STZ)-induced diabetic Wistar rats. The aglycones apigenin, chrysoeriol and genistein, the monoglucosides apigenin 7-O-glucoside, luteolin 7-O-glucoside and genistein 7-O-glucoside and the diglycosides rutin and luteolin 7,3′-di-O-glucoside were administered i.p. for 7 days (4 mg/kg b.w./day). The protective effect of these compounds over liver and kidneys of STZ–diabetic models was also evaluated by the determination of seric AST, ALT and urea levels. After 7 days of treatment, apigenin, chrysoeriol and genistein significantly lowered the blood glucose levels of diabetic animals; this effect was more pronounced (P < 0.01) in the oral glucose tolerance test. Glucose tolerance was also significantly improved in the rutin (P < 0.01) and in the genistein 7–O–glucoside (P < 0.05) treated groups. In addition, almost all the tested compounds effectively protected the liver and kidneys against STZ-induced damage in rats | por |
| dc.description.sponsorship | FCT | por |
| dc.identifier.citation | Rauter, A.P.; Martins, A.; Borges, C.; Mota-Filipe, H.; Pinto R., Sepodes, B. Justino, J. (2010) - Antihyperglycaemic and protective effects of flavonoids on streptozotocin–induced diabetic rats. Phytotherapy Research, 24: S133-S138. Retrieved from: http://onlinelibrary.wiley.com/doi/10.1002/ptr.3017/pdf DOI: 10.1002/ptr.3017 | por |
| dc.identifier.issn | 1099-1573 | |
| dc.identifier.uri | http://hdl.handle.net/10400.15/487 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | John Wiley | por |
| dc.relation | FCT - Projecto PTDC/QUI/6765/2006 | por |
| dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/ptr.3017/pdf | por |
| dc.subject | flavonoids | por |
| dc.subject | antihyperglycaemic effect | por |
| dc.subject | liver protection | por |
| dc.subject | kidney protection | por |
| dc.subject | Genista tenera | por |
| dc.subject | propriedade medicinal | por |
| dc.subject | flavonoíde | por |
| dc.subject | animal de laboratório | por |
| dc.subject | Diabetes | por |
| dc.title | Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | S138 | por |
| oaire.citation.startPage | S133 | por |
| oaire.citation.title | Phytotherapy Research | por |
| person.familyName | Justino | |
| person.givenName | Jorge | |
| person.identifier.orcid | 0000-0003-3114-5926 | |
| rcaap.rights | restrictedAccess | por |
| rcaap.type | article | por |
| relation.isAuthorOfPublication | 3e483773-36b8-4a7b-82f3-c0a39f6a7fa9 | |
| relation.isAuthorOfPublication.latestForDiscovery | 3e483773-36b8-4a7b-82f3-c0a39f6a7fa9 |