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A new lupene triterpenetriol and anticholinesterase activity of Salvia sclareoides

2007-12Artigo científico Acesso aberto
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authorProfile.affiliationInstituto Politécnico de Santarém, Escola Superior Agrária de Santarémpt_PT
dc.contributor.authorRauter, A. P.
dc.contributor.authorBranco, I.
dc.contributor.authorLopes, R. G.
dc.contributor.authorJustino, Jorge
dc.contributor.authorSilva, Filipa
dc.contributor.authorNoronha, J. P.
dc.contributor.authorCabrita, E. J.
dc.contributor.authorBrouard, I.
dc.contributor.authorBermejo, J.
dc.date.accessioned2011-08-18T09:07:13Z
dc.date.available2011-08-18T09:07:13Z
dc.date.issued2007-12
dc.description.abstractA new lupene triterpenetriol was isolated from the acetone extract of the aerial parts of Salvia sclareoides and characterised as (1β,3β)-lup-20(29)-ene-1,3,30-triol (1). In addition, nepetidin (2), nepeticin (3), lupendiol (4), (1β,11α)-dihydroxy-lup-20(29)-en-3-one (5), ursolic acid (6), sumaresinolic acid (7) and hederagenin (8), were identified in this Salvia sp. To the best of our knowledge, the compounds 2 and 7 are new constituents in Salvia spp. The acetone, ethanol, butanol and water extracts of the plant were screened for the in vitro inhibitory activity of acetylcholinesterase (AChE) and butyrilcholinesterase (BChE), enzymes which play a role in the Alzheimer disease. All extracts inhibited acetylcholinesterase activity at 10 μg/ml, a remarkable activity since the standard drug rivastigmine does not inhibit acetylcholinesterase at the same concentration. Regarding the butyrilcholinesterase, the acetone extract at 1000 μg/ml was able to inhibit completely the enzyme activity and the butanol and ethanol extracts, at this concentration, produced a potent inhibition of BchE.por
dc.identifier.citationRauter, A. P. ; Branco, I. ; Lopes, R. G. ; Justino, J.1; Silva, F.V. M.1; Noronha, J. P.; Cabrita, E. J. ; Brouard, I. ; Bermejo, J. (2007) – A new lupene triterpenetriol and anticholinesterase activity of Salvia sclareoides. Fitoterapia, 78 (7-8): 474-481. DOI: 10.1016/j.fitote.2007.02.013por
dc.identifier.issn0367-326X
dc.identifier.urihttp://hdl.handle.net/10400.15/497
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relationFCT- Post-Doctoral Grant BPD 14408/2003.por
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0367326X07001190por
dc.subjectSalvia sclareoidespor
dc.subjectmedicinal-plantspor
dc.subjectessencial oilpor
dc.subjectTriterpenoidpor
dc.subject(1β,3β)-Lup-20(29)-ene-1,3,30-triolpor
dc.subjectAcetylcholinesterasepor
dc.subjectButyrilcholinesterasepor
dc.subjectplanta medicinalpor
dc.subjectóleo essencialpor
dc.titleA new lupene triterpenetriol and anticholinesterase activity of Salvia sclareoidespor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceAmsterdampor
oaire.citation.endPage481por
oaire.citation.startPage474por
oaire.citation.titleFitoterapiapor
person.familyNameJustino
person.familyNameVinagre Marques da Silva
person.givenNameJorge
person.givenNameFilipa
person.identifierhttps://scholar.google.pt/citations?hl=pt-PT&user=TcUz9ZAAAAAJ
person.identifier.ciencia-idB610-66DA-A3AC
person.identifier.orcid0000-0003-3114-5926
person.identifier.orcid0000-0003-4700-2938
person.identifier.scopus-author-id22942414000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlepor
relation.isAuthorOfPublication3e483773-36b8-4a7b-82f3-c0a39f6a7fa9
relation.isAuthorOfPublication344bf736-31c9-4a35-844c-67a176174a44
relation.isAuthorOfPublication.latestForDiscovery3e483773-36b8-4a7b-82f3-c0a39f6a7fa9

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