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Effects of 12-week moderate aerobic exercise on ROCK2 activity, hs-CRP and glycemic index in obese patients with impaired glucose tolerance

2022-10-20Artigo científico Acesso restrito
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dc.contributor.authorKargarfard, Mehdi
dc.contributor.authorNobari, Hadi
dc.contributor.authorKamyar, Kian
dc.contributor.authorZadeh, Ali Khosravi
dc.contributor.authorOliveira, Rafael
dc.date.accessioned2023-04-13T13:31:05Z
dc.date.available2023-10-20T00:30:16Z
dc.date.issued2022-10-20
dc.description.abstractBackground: : Obesity is a chronic low-grade inflammatory state that is related to prediabetes, increased Rhoassociated kinase 2 (ROCK2) activity and concentration of high-sensitivity C-reactive protein (hs-CRP). Therefore, the study was conducted to investigate the effects of 12-week moderate aerobic exercise on ROCK2 activity, hs-CRP, glycosylated hemoglobin A1C (HbA1c), and glycemic index in obese patients with impaired glucose tolerance. Methods: : In a quasi-experimental design with pre and post-test, 42 obese men with prediabetes [mean±SD, age: 44.73 ± 3.30 years, body mass index (BMI): 33.22 ± 2.05 kg/m2 , HbA1c: 6.29% ± 0.75] were allocated into two randomized homogeneous groups: Aerobic training group (AT, n = 22) or control group (C, n = 20). Exercise group performed a moderate aerobic exercise program three sessions per week, 60 min per session for 12 weeks. Body mass, BMI, maximal oxygen consumption (VO2max), serum levels of fasting blood glucose (FBG), insulin, insulin resistance (HOMA-IR), homeostasis model assessment of β-cell function (HOMA-B); HbA1c, hs-CRP, or ROCK2 activity were measured before and after the study period. The data were analyzed using repeated measures ANOVA 2 × 2 and paired sample t-test at a significant level of p < 0.05. Results: : AT caused a significant reduction in body mass (p ≤ 0.001), BMI (p = 0.04), HOMA-B (p = 0.003), serum levels of FBG (p = 0.002), HbA1c (p = 0.039), hs-CRP (p ≤ 0.0001), and ROCK2 activity (p = 0.001). In contrast, in the same group, a significant increase was observed in VO2max (p = 0.04). Conclusion: : The results of this study showed that moderate aerobic exercise was an effective and safe method to prevent type 2 diabetes and cardiovascular diseases in obese men with prediabetes by improving glucose metabolism, reduction of body mass, ROCK2 activity and serum levels of hs-CRP.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationKargarfard,M., Nobari,H., Kamyar,K.,Zadeh, A.K. & Oliveira,R. (2022). Effects of 12-week moderate aerobic exercise on ROCK2 activity, hs-CRP and glycemic index in obese patients with impaired glucose tolerance. Physiology & Behavior, 257(dec), 113976. DOI 10.1016/j.physbeh.2022.113976pt_PT
dc.identifier.doi10.1016/j.physbeh.2022.113976pt_PT
dc.identifier.issn0031-9384
dc.identifier.urihttp://hdl.handle.net/10400.15/4399
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0031938422002827?via%3Dihubpt_PT
dc.subjectobesitypt_PT
dc.subjectprediabetespt_PT
dc.subjectrhoassociated kinase 2 activitypt_PT
dc.subjecths-CRPpt_PT
dc.subjectcardiorespiratory capacitypt_PT
dc.titleEffects of 12-week moderate aerobic exercise on ROCK2 activity, hs-CRP and glycemic index in obese patients with impaired glucose tolerancept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage113976pt_PT
oaire.citation.titlePhysiology & Behaviorpt_PT
person.familyNameOliveira
person.givenNameRafael
person.identifier.ciencia-id9C16-7F53-1375
person.identifier.orcid0000-0001-6671-6229
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication048765fe-a23f-4a68-9e6e-f278321223ac
relation.isAuthorOfPublication.latestForDiscovery048765fe-a23f-4a68-9e6e-f278321223ac

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