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Association between ACE D allele and elite short distance swimming

2009-08Journal article Open access
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dc.contributor.authorCosta, Aldo Matos
dc.contributor.authorSilva, António José
dc.contributor.authorGarrido, Nuno Domingos
dc.contributor.authorLouro, Hugo
dc.contributor.authorde Oliveira, Ricardo Jacó
dc.contributor.authorBreitenfeld, Luiza
dc.date.accessioned2021-08-08T16:20:01Z
dc.date.available2021-08-08T16:20:01Z
dc.date.issued2009-08
dc.description.abstractThe influence of ACE gene on athletic performance has been widely explored, and most of the published data refers to an I/D polymorphism leading to the presence (I allele) or absence (D allele) of a 287-bp sequence in intron 16, determining ACE activity in serum and tissues. A higher I allele frequency has been reported among elite endurance athletes, while the D allele was more frequent among those engaged in more power-orientated sports. However, on competitive swimming, the reproducibility of such associations is controversial. We thus compared the ACE genotype of elite swimmers with that of non-elite swimming cohort and of healthy control subjects. We thus sought an association of the ACE genotype of elite swimmers with their competitive distance. 39 Portuguese Olympic swimming candidates were classified as: short (<200 m) and middle (400-1,500 m) distance swimmers, respectively. A group of 32 non-elite swimmers were studied and classified as well, and a control group (n = 100) was selected from the Portuguese population. Chelex 100 was used for DNA extraction and genotype was determined by PCR-RFLP methods. We found that ACE genotype distribution and allelic frequency differs significantly by event distance only among elite swimmers (P < or = 0.05). Moreover, the allelic frequency of the elite short distance swimmers differed significantly from that of the controls (P = 0.021). No associations were found between middle distance swimmers and controls. Our results seem to support an association between the D allele and elite short distance swimming.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCosta, A.M., Silva, A.J., Garrido, N.D., Louro,H., de Oliveira, R.J.& Breitenfeld,L. (2009). Association between ACE D allele and elite short distance swimming. Eur J Appl Physiol 106, 785–790. https://doi.org/10.1007/s00421-009-1080-zpt_PT
dc.identifier.doi10.1007/s00421-009-1080-zpt_PT
dc.identifier.issn1439-6327
dc.identifier.urihttp://hdl.handle.net/10400.15/3565
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationPortuguese Science and Technology Foundation (SFRH/BD/40243/2007)pt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00421-009-1080-z#Ack1pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectadolescentpt_PT
dc.subjectallelespt_PT
dc.subjectfemalespt_PT
dc.subjecthumanspt_PT
dc.subjectmalept_PT
dc.subjectpeptidyl-dipeptidase Apt_PT
dc.subjectphysical endurancept_PT
dc.subjectphysical exertionpt_PT
dc.subjectpolymorphismpt_PT
dc.subjectswimmingpt_PT
dc.subjectyoung adultpt_PT
dc.subjectsingle nucleotidept_PT
dc.titleAssociation between ACE D allele and elite short distance swimmingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage790pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage785pt_PT
oaire.citation.titleEuropean journal of applied physiologypt_PT
oaire.citation.volume106pt_PT
person.familyNameLouro
person.givenNameHugo
person.identifier1741645
person.identifier.ciencia-id8019-E11F-9609
person.identifier.orcid0000-0001-5635-2476
person.identifier.scopus-author-id26425142800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf29a2faa-09b7-43c3-b023-0684d0a5d8d3
relation.isAuthorOfPublication.latestForDiscoveryf29a2faa-09b7-43c3-b023-0684d0a5d8d3

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