Repository logo
 
Publication

Impact of flavonols on cardiometabolic biomarkers: a meta‐analysis of randomized controlled human trials to explore the role of inter‐Individual variability

2017Journal article Open access
Simple item page
authorProfile.affiliationInstituto Politécnico de Santarém, Escola Superior Agrária de Santarémpt_PT
dc.contributor.authorMenezes, R.
dc.contributor.authorRodriguez-Mateos, A.
dc.contributor.authorKaltsatou, A.
dc.contributor.authorGonzález-Sarrías, A.
dc.contributor.authorGreyling, A.
dc.contributor.authorGiannaki, C.
dc.contributor.authorAndres-Lacueva, C
dc.contributor.authorMilenkovic, D.
dc.contributor.authorGibney E., E.
dc.contributor.authorDumont, J.
dc.contributor.authorSchär, M.
dc.contributor.authorGarcia-Aloy, M.
dc.contributor.authorPalma-Duran, S.
dc.contributor.authorRuskovska, T.
dc.contributor.authorMaksimova, V.
dc.contributor.authorCombet, E.
dc.contributor.authorPinto, Paula
dc.date.accessioned2017-08-25T10:46:08Z
dc.date.available2017-08-25T10:46:08Z
dc.date.issued2017
dc.descriptionArtigo de revisão integrante o número especial da revista Nutrients: Selected papers from the 1st International Food Bioactives and Health Conference 2016pt_PT
dc.description.abstractSeveral epidemiological studies have linked flavonols with decreased risk of cardiovascular disease (CVD). However, some heterogeneity in the individual physiological responses to the consumption of these compounds has been identified. This meta‐analysis aimed to study the effect of flavonol supplementation on biomarkers of CVD risk such as, blood lipids, blood pressure and plasma glucose, as well as factors affecting their inter‐individual variability. Data from 18 human randomized controlled trials were pooled and the effect was estimated using fixed or random effects meta‐analysis model and reported as difference in means (DM). Variability in the response of blood lipids to supplementation with flavonols was assessed by stratifying various population subgroups: age, sex, country, and health status. Results showed significant reductions in total cholesterol (DM = −0.10 mmol/L; 95% CI: −0.20, −0.01), LDL cholesterol (DM = −0.14 mmol/L; Nutrients 2017, 9, 117 2 of 21 95% CI: −0.21, 0.07), and triacylglycerol (DM = −0.10 mmol/L; 95% CI: −0.18, 0.03), and a significant increase in HDL cholesterol (DM = 0.05 mmol/L; 95% CI: 0.02, 0.07). A significant reduction was also observed in fasting plasma glucose (DM = −0.18 mmol/L; 95%CI: −0.29, −0.08), and in blood pressure (SBP: DM = −4.84 mmHg; 95% CI: −5.64, −4.04; DBP: DM = −3.32 mmHg; 95% CI: -4.09, -2.55). Subgroup analysis showed a more pronounced effect of flavonol intake in participants from Asian countries and in participants with diagnosed disease or dyslipidemia, compared to healthy and normal baseline values. In conclusion, flavonol consumption improved biomarkers of CVD risk, however, country of origin and health status may influence the effect of flavonol intake on blood lipid levels.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMenezes; R.; Rodriguez-Mateos, A.; Kaltsatou, A.; González-Sarrías, A.; Greyling, A.; Giannaki, C.; Andres-Lacueva, C.; Milenkovic, D.; Gibney E. R.; Dumont, J.; Schär, M.; Garcia-Aloy, M.; Palma-Duran, S.; Ruskovska, T.; Maksimova, V.; Combet, E. & Pinto P.(2017). Impact of flavonols on cardiometabolic biomarkers: a meta‐analysis of randomized controlled human trials to explore the role of inter‐Individual variability. Nutrients, 9: 117pt_PT
dc.identifier.doi10.3390/nu9020117pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.15/1890
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttp://www.mdpi.com/2072-6643/9/2/117pt_PT
dc.subjectflavonolspt_PT
dc.subjectquercetinpt_PT
dc.subjectcardiovascular disease;pt_PT
dc.subjectmeta-analysispt_PT
dc.subjectinterindividual variabilitypt_PT
dc.subjectblood lipidspt_PT
dc.subjectblood pressurept_PT
dc.subjectglucosept_PT
dc.titleImpact of flavonols on cardiometabolic biomarkers: a meta‐analysis of randomized controlled human trials to explore the role of inter‐Individual variabilitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceBasel (CH)pt_PT
oaire.citation.startPage117pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume9pt_PT
person.familyNamePaula S F S Pinto
person.givenNameMaria
person.identifier.ciencia-id011F-62A8-AE04
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2260faef-53cb-403f-a0ea-637298da3dc7
relation.isAuthorOfPublication.latestForDiscovery2260faef-53cb-403f-a0ea-637298da3dc7

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
PIntoP_flaven_NutrientsFev2017.pdf
Size:
2.16 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artigos em revistas internacionais_ESAS