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A systematic review and meta-analysis of the effects of flavanol-containing tea, cocoa and apple products on body composition and blood lipids: exploring the factors responsible for variability in their efficacy

2017Journal article Open access
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authorProfile.affiliationInstituto Politécnico de Santarém, Escola Superior Agrária de Santarémpt_PT
dc.contributor.authorGonzález-Sarrías, A.
dc.contributor.authorCombet, E.
dc.contributor.authorPinto, Paula
dc.contributor.authorMena, P.
dc.contributor.authorDall’Asta, M.
dc.contributor.authorGarcia-Aloy, M.
dc.contributor.authorRodríguez-Mateos, A.
dc.contributor.authorGibney, E. R.
dc.contributor.authorDumont, J.
dc.contributor.authorMassaro, M.
dc.contributor.authorSánchez-Meca, J.
dc.contributor.authorMorand, C.
dc.contributor.authorGarcía-Conesa, M. T.
dc.date.accessioned2017-08-25T09:56:22Z
dc.date.available2017-08-25T09:56:22Z
dc.date.issued2017
dc.description.abstractSeveral randomized controlled trials (RCTs) and meta-analyses support the benefits of flavanols on cardiometabolic health, but the factors affecting variability in the responses to these compounds have not been properly assessed. The objectives of this meta-analysis were to systematically collect the RCTs-based-evidence of the effects of flavanol-containing tea, cocoa and apple products on selected biomarkers of cardiometabolic risk and to explore the influence of various factors on the variability in the responses to the consumption of these products. A total of 120 RCTs were selected. Despite a high heterogeneity, the intake of the flavanol-containing products was associated using a random model with changes (reported as standardized difference in means (SDM)) in body mass index (−0.15, p < 0.001), waist circumference (−0.29, p < 0.001), total-cholesterol (−0.21, p < 0.001), LDL-cholesterol (−0.23, p < 0.001), and triacylglycerides (−0.11, p = 0.027), and with an increase of HDL-cholesterol (0.15, p = 0.005). Through subgroup analyses, we showed the influence of baseline-BMI, sex, source/form of administration, medication and country of investigation on some of the outcome measures and suggest that flavanols may be more effective in specific subgroups such as those with a BMI ≥ 25.0 kg/m2, non-medicated individuals or by specifically using tea products. This meta-analysis provides the first robust evidence of the effects induced by the consumption of flavanol-containing tea, cocoa and apple products on weight and lipid biomarkers and shows the influence of various factors that can affect their bioefficacy in humans. Of note, some of these effects are quantitatively comparable to those produced by drugs, life-style changes or other natural products. Further, RCTs in well-characterized populations are required to fully comprehend the factors affecting inter-individual responses to flavanol and thereby improve flavanols efficacy in the prevention of cardiometabolic disorderspt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGonzález-Sarrías, A.; Combet, E.; Pinto, P.; Mena, P.; Dall’Asta, M.; Garcia-Aloy, M.; Rodríguez-Mateos, A.; Gibney, E.R.; Dumont, J.; Massaro, M.; Sánchez-Meca, J.; Morand, C.& García-Conesa, M.-T.(2017). A systematic review and meta-analysis of the effects of flavanol-containing tea, cocoa and apple products on body composition and blood lipids: exploring the factors responsible for variability in their efficacy. Nutrients, 9, 746.pt_PT
dc.identifier.doi10.3390/nu9070746pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.15/1888
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCOST Action FA1403—POSITIVe “Interindividual variation in response to consumption of plant food bioactives and determinants involved” supported by COST (European Cooperation in Science and Technology)pt_PT
dc.relationPCIN-2014-133-MINECO, Spainpt_PT
dc.relationCIBERFESpt_PT
dc.relation.publisherversionhttp://www.mdpi.com/2072-6643/9/7/746pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectflavanolspt_PT
dc.subjectteapt_PT
dc.subjectcocoapt_PT
dc.subjectapplept_PT
dc.subjectcardiometabolic disorderspt_PT
dc.subjectmeta-analysispt_PT
dc.subjectinterindividual variabilitypt_PT
dc.subjectblood lipidspt_PT
dc.subjectbody mass indexpt_PT
dc.subjectwaist circumferencept_PT
dc.titleA systematic review and meta-analysis of the effects of flavanol-containing tea, cocoa and apple products on body composition and blood lipids: exploring the factors responsible for variability in their efficacypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceBasel (CH)pt_PT
oaire.citation.startPage746pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume9pt_PT
person.familyNamePaula S F S Pinto
person.givenNameMaria
person.identifier.ciencia-id011F-62A8-AE04
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2260faef-53cb-403f-a0ea-637298da3dc7
relation.isAuthorOfPublication.latestForDiscovery2260faef-53cb-403f-a0ea-637298da3dc7

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