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Polyphenols journey through blood-brain barrier towards neuronal protection

2017Journal article Open access
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authorProfile.affiliationInstituto Politécnico de Santarém, Escola Superior Agrária de Santarémpt_PT
dc.contributor.authorFigueira, I.
dc.contributor.authorGarcia, G.
dc.contributor.authorPimpão, R.
dc.contributor.authorTerrasso, C.
dc.contributor.authorCosta, I.
dc.contributor.authorAlmeida, A.
dc.contributor.authorTavares, L.
dc.contributor.authorPais, T.
dc.contributor.authorPinto, Paula
dc.contributor.authorVentura, M.
dc.contributor.authorFilipe, A.
dc.contributor.authorMcDougall, G.
dc.contributor.authorStewart, D:
dc.contributor.authorKim, S.
dc.contributor.authorPalmela, I.
dc.contributor.authorBrites, D.
dc.contributor.authorBrito, M.
dc.contributor.authorSantos, C.
dc.date.accessioned2018-05-22T16:44:10Z
dc.date.available2018-05-22T16:44:10Z
dc.date.issued2017
dc.description.abstractAge-related complications such as neurodegenerative disorders are increasing and remain cureless. The possibility of altering the progression or the development of these multifactorial diseases through diet is an emerging and attractive approach with increasing experimental support. We examined the potential of known bioavailable phenolic sulfates, arising from colonic metabolism of berries, to infuence hallmarks of neurodegenerative processes. In silico predictions and in vitro transport studies across blood-brain barrier (BBB) endothelial cells, at circulating concentrations, provided evidence for diferential transport, likely related to chemical structure. Moreover, endothelial metabolism of these phenolic sulfates produced a plethora of novel chemical entities with further potential bioactivies. Pre-conditioning with phenolic sulfates improved cellular responses to oxidative, excitotoxicity and infammatory injuries and this attenuation of neuroinfammation was achieved via modulation of NF-κB pathway. Our results support the hypothesis that these small molecules, derived from dietary (poly)phenols may cross the BBB, reach brain cells, modulate microglia-mediated infammation and exert neuroprotective efects, with potential for alleviation of neurodegenerative diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFigueira, I.; Garcia, G.; Pimpao, R.C.; Terrasso, A.P.; Costa, I.; Almeida, A. F.; Tavares, L.; Pais, T. F.; Pinto, P.;Ventura, M. R.; Filipe, A.; McDougall, G. J.; Stewart, D.; Kim, S.; Palmela, I.; Brites, D.; Brito, M. A.; Brito, C. and Santos, C. N.(2017). Polyphenols journey through blood-brain barrier towards neuronal protection. Scientific reports, 7: 11456pt_PT
dc.identifier.doi10.1038/s41598-017-11512-6pt_PT
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.15/2222
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Publishing Grouppt_PT
dc.relationF/01097/2013 SFRH/BD/86584/2012 PD/BD/52473/2014 SFRH/BD/63615/2009 UID/DTP/04138/2013pt_PT
dc.relationFA1005-INFOGEST FA1403-POSITIVept_PT
dc.relationLISBOA-01-0145-FEDER-007344pt_PT
dc.relationFP7-613793pt_PT
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-017-11512-6.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectComposto fenólicopt_PT
dc.titlePolyphenols journey through blood-brain barrier towards neuronal protectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceLondonpt_PT
oaire.citation.endPage16pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume7pt_PT
person.familyNamePaula S F S Pinto
person.givenNameMaria
person.identifier.ciencia-id011F-62A8-AE04
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2260faef-53cb-403f-a0ea-637298da3dc7
relation.isAuthorOfPublication.latestForDiscovery2260faef-53cb-403f-a0ea-637298da3dc7

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