Loading...
2 results
Search Results
Now showing 1 - 2 of 2
- Phase angle cutoff value as a marker of the health status and functional capacity in breast cancer survivorsPublication . Martins, Alexandre; Oliveira, Rafael; Brito, João; Costa, Tiago; Ramalho, Fatima; Pimenta, Nuno; Santos-Rocha, RAAccurate predictive tools are key factors for cancer care. Phase angle (PhA) has been proposed as a marker of cellular health, particularly of cell-membrane integrity. Cutoff values have been proposed, including for cancer survivors. This study aimed to assess the usefulness of the proposed PhA cutoff, as a marker of bioelectrical impedance analysis (BIA) assessed health-status, and functional capacity in breast cancer (BC) survivors. This cross-sectional study included 25 women (50.6 ± 8.6 yrs) survivors of BC, divided into two groups according to the PhA reference value of 5.6◦ (group 1 [G1]: PhA ≤ 5.6◦ [n=13]; group 2 [G2]: PhA > 5.6◦ [n=12]) (Gupta et al. 2008). BIA-assessed health status parameters included: extracellular water (ECW), intracellular water (ICW), total body water (TBW), PhA, body mass, fat-free mass, muscle mass, body cell mass (BCM). Four functional tests were performed: 30 s chair-stand test, timed up and go test, ball throw test and 6-minute walking test. Results showed G2 had lower ECW/ICW ratio (p=0.001; ES=1.2), ECW/BCM ratio (p=0.001; ES=3.2) and ECW/TBW ratio (p=0.001; ES=4.8). There was no difference in functional capacity between groups. The results of the present study show that patients with higher PhA values have a higher ICW values and preservation in the ECW/ICW ratio, suggesting it’s a better cell membrane quality and integrity. Relation of both PhA and cell membrane integrity with functional capacity warrants further research.
- Comparative study of water parameters and functional capacity in women survivors of breast cancer as a function of the cut-off value of the phase anglePublication . Martins, Alexandre; Oliveira, Rafael; Brito, João; Costa, Tiago; Ramalho, Fátima; Pimenta, Nuno; Santos-Rocha, RAIn 2018, breast cancer (BC) registered 2,088,849 new cases worldwide and 626,679 deaths attributed to the disease (IARC, 2019). Phase angle (PhA) has been considered effective in assessing cell integrity in cancer patients (Schulz et al., 2017). Low PhA values are predictors of lower survival in this population (Pereira et al., 2018).