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Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction

2021-01-19Journal article Open access
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dc.contributor.authorAuxtero, Maria D.
dc.contributor.authorChalante, Susana
dc.contributor.authorAbade, Mário R.
dc.contributor.authorJorge, Rui
dc.contributor.authorFernandes, Ana I.
dc.date.accessioned2021-11-15T13:17:24Z
dc.date.available2021-11-15T13:17:24Z
dc.date.issued2021-01-19
dc.description.abstractLate-life mild cognitive impairment and dementia represent a significant burden on healthcare systems and a unique challenge to medicine due to the currently limited treatment options. Plant phytochemicals have been considered in alternative, or complementary, prevention and treatment strategies. Herbals are consumed as such, or as food supplements, whose consumption has recently increased. However, these products are not exempt from adverse effects and pharmacological interactions, presenting a special risk in aged, polymedicated individuals. Understanding pharmacokinetic and pharmacodynamic interactions is warranted to avoid undesirable adverse drug reactions, which may result in unwanted side-effects or therapeutic failure. The present study reviews the potential interactions between selected bioactive compounds (170) used by seniors for cognitive enhancement and representative drugs of 10 pharmacotherapeutic classes commonly prescribed to the middle-aged adults, often multimorbid and polymedicated, to anticipate and prevent risks arising from their co-administration. A literature review was conducted to identify mutual targets affected (inhibition/induction/substrate), the frequency of which was taken as a measure of potential interaction. Although a limited number of drugs were studied, from this work, interaction with other drugs affecting the same targets may be anticipated and prevented, constituting a valuable tool for healthcare professionals in clinical practice.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAuxtero, M.D.; Chalante, S.; Abade, M.R.; Jorge, R.; Fernandes, A.I. Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction. Pharmaceutics 2021, 13, 124. https://doi.org/ 10.3390/pharmaceutics13010124pt_PT
dc.identifier.doi10.3390/pharmaceutics13010124pt_PT
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/10400.15/3687
dc.language.isoengpt_PT
dc.publisherMDPIpt_PT
dc.relationThis open access publication was funded by FCT (Fundação para a Ciência e a Tecnologia, I.P., Portugal) under project UIDB/04585/2020.pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectherb–drug interactionspt_PT
dc.subjectbotanicalspt_PT
dc.subjectfood supplementspt_PT
dc.subjectnootropicspt_PT
dc.subjectphytochemicalspt_PT
dc.subjectnutraceuticalspt_PT
dc.subjectpharmacokineticspt_PT
dc.subjectcognitive dysfunctionpt_PT
dc.titlePotential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunctionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage124pt_PT
oaire.citation.titlePharmaceuticspt_PT
oaire.citation.volume13pt_PT
person.familyNameJorge
person.givenNameRui
person.identifier.ciencia-id7D1D-0A75-A4B7
person.identifier.orcid0000-0002-5261-2688
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd3474cac-b596-4a55-8584-41b8e5efc137
relation.isAuthorOfPublication.latestForDiscoveryd3474cac-b596-4a55-8584-41b8e5efc137

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