Samakosh, H.M.NMaktoubian, M.Doost, S.P.R.Oliveira, RafaelBadicu, G.Al-Mhanna, S.B.Hassanzadeh, M.Amadekhiar, P.Vaskasi, R.R.Oliveira, Rafael2025-07-282025-07-282025-07-21Samakosh, H.M.N, Maktoubian, M., Doost, S.P.R., Oliveira,R., Badicu, G., Al-Mhanna, S.B., Hassanzadeh, M., Amadekhiar, P. & Vaskasi, R.R. (2025). Active and sham transcranial direct-current stimulation (tDCS) plus core stability on the knee kinematic and performance of the lower limb of the soccer players with dynamic knee valgus; two armed randomized clinical trial[J]. AIMS Neuroscience, 12(3): 312-331. doi: 10.3934/Neuroscience.20250172373-7972http://hdl.handle.net/10400.15/5827Dynamic knee valgus (DKV) is a prevalent risk factor for anterior cruciate ligament (ACL) injuries in soccer players, particularly during noncontact mechanisms. Transcranial direct-current stimulation (tDCS) and core stability exercises have shown promise in enhancing motor control and biomechanical alignment, but their combined effects on DKV remain unexplored. This study aimed to evaluate the efficacy of active versus sham tDCS combined with core stability exercises on knee kinematic alignment and lower limb performance in young male soccer players with DKV. In this double-blind, randomized controlled trial, 42 male soccer players (aged 18–25 years) with DKV were randomly assigned to either an active tDCS group (n = 21) or a sham tDCS group (n = 21). Both groups underwent 8 weeks of core stability exercises (3 sessions/week, 30 minutes/session) preceded by 15 minutes of active (2 mA) or sham tDCS targeting the primary motor cortex (M1). The primary outcome was the frontal plane projection angle (FPPA) during a single-leg landing task, measured using 2D video analysis. Secondary outcomes included vertical jump height and 8-hop test time. Outcomes were assessed at baseline and post-intervention. A 2 × 2 mixed-model ANOVA with Bonferroni-corrected post hoc tests was used for statistical analysis via SPSS27. The active tDCS group showed significantly greater improvements in FPPA (+5.65% vs. +2.26%, p < 0.001, 𝜂p² = 0.82), vertical jump height (+25.30% vs. +10.45%, p < 0.001, 𝜂p² = 0.75), and 8-hop test time (−21.05% vs. −14.27%, p < 0.001, � �p² = 0.68) compared to the sham group. Both groups improved from baseline, but the active tDCS group exhibited larger effect sizes across all outcomes. Active tDCS combined with core stability exercises significantly enhanced knee kinematic alignment and lower limb performance in soccer players with DKV compared to sham tDCS. These findings suggest that neuromodulation, when paired with targeted exercise, is a promising strategy for injury prevention and performance enhancement in athletes. Further research is needed to explore long-term effects and applicability to diverse populations.engdynamic knee valgustranscranial direct-current stimulationcore stabilityknee kinematicssoccerinjury preventionresearch article10.3934/Neuroscience.2025017