Sá Filho, Alberto SouzaCheniaux, Eliede Paula, Carolina CavalcanteMurillo-Rodriguez, EricTeixeira, DiogoMonteiro, DiogoCid, LuisYamamoto, TetsuyaTelles-Correia, DiogoImperatori, ClaudioBudde, HenningMachado, Sergio2020-08-122021-08-082020-08-07Sá Filho,A.S. Cheniaux,E., Paula,C.C., Murillo-Rodriguez,E., Teixeira,D., Monteiro,D., Cid,L., Tetsuya,Y, Telles-Correia, D., Imperatori,C., Budde,H. & Machado,S. (2020) Exercise is medicine: a new perspective for health promotion in bipolar disorder, Expert Review of Neurotherapeutics, DOI: 10.1080/14737175.2020.18073291473-7175http://hdl.handle.net/10400.15/3006Similar effects in reducing the symptoms of the mood disorder are reported in the literature compared the action of drugs and aerobic exercise sessions, demonstrating the potential of exercise in the control and mood stabilization. Therefore, there are many reasons to believe that the increased cardiorespiratory fitness (VO2max) can be an important means of protection and a reducing potential of physical and mental damage in bipolar disorders (BD). This review will highlight the current pattern of response of exercise on the pathophysiology of BD, relating the possible mechanisms, and hypotheses based on exercises.engbipolar disordermonoaminergic systemcatecholaminesexercisehigh intensity interval trainingjournal article10.1080/14737175.2020.1807329