Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.15/497
Título: A new lupene triterpenetriol and anticholinesterase activity of Salvia sclareoides
Autor: Rauter, A. P.
Branco, I.
Lopes, R. G.
Justino, Jorge
Silva, Filipa
Noronha, J. P.
Cabrita, E. J.
Brouard, I.
Bermejo, J.
Palavras-chave: Salvia sclareoides
medicinal-plants
essencial oil
Triterpenoid
(1β,3β)-Lup-20(29)-ene-1,3,30-triol
Acetylcholinesterase
Butyrilcholinesterase
planta medicinal
óleo essencial
Data: Dez-2007
Editora: Elsevier
Citação: Rauter, A. P. ; Branco, I. ; Lopes, R. G. ; Justino, J.1; Silva, F.V. M.1; Noronha, J. P.; Cabrita, E. J. ; Brouard, I. ; Bermejo, J. (2007) – A new lupene triterpenetriol and anticholinesterase activity of Salvia sclareoides. Fitoterapia, 78 (7-8): 474-481. DOI: 10.1016/j.fitote.2007.02.013
Resumo: A new lupene triterpenetriol was isolated from the acetone extract of the aerial parts of Salvia sclareoides and characterised as (1β,3β)-lup-20(29)-ene-1,3,30-triol (1). In addition, nepetidin (2), nepeticin (3), lupendiol (4), (1β,11α)-dihydroxy-lup-20(29)-en-3-one (5), ursolic acid (6), sumaresinolic acid (7) and hederagenin (8), were identified in this Salvia sp. To the best of our knowledge, the compounds 2 and 7 are new constituents in Salvia spp. The acetone, ethanol, butanol and water extracts of the plant were screened for the in vitro inhibitory activity of acetylcholinesterase (AChE) and butyrilcholinesterase (BChE), enzymes which play a role in the Alzheimer disease. All extracts inhibited acetylcholinesterase activity at 10 μg/ml, a remarkable activity since the standard drug rivastigmine does not inhibit acetylcholinesterase at the same concentration. Regarding the butyrilcholinesterase, the acetone extract at 1000 μg/ml was able to inhibit completely the enzyme activity and the butanol and ethanol extracts, at this concentration, produced a potent inhibition of BchE.
Peer review: yes
URI: http://hdl.handle.net/10400.15/497
ISSN: 0367-326X
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0367326X07001190
Aparece nas colecções:Artigos em revistas internacionais_ESAS

Ficheiros deste registo:
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JustinoJ_SalviaFitoterapia2007.pdf20,56 kBAdobe PDFVer/Abrir
a_new_lupene_triterpenetriol_and_anticholinesterase_activity_of_salvia_sclareoides_2007.pdf3,59 MBAdobe PDFVer/Abrir


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